In conclusion, clomiphene citrate remains a cornerstone off-label therapy for hypogonadal men desiring fertility, with strong evidence of safety and efficacy in raising testosterone and helping sperm parameter

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Enclomiphene is generally well tolerated compared to exogenous testosterone replacement, particularly because it works through the body’s own hormonal axis rather than introducing an external hormon

It is tempting to speculate that the effect of daily administration of an anti-oestrogen such as enclomiphene citrate results in the restoration of the normal underlying LH and FSH patern that has been lost in men with secondary hypogonadis

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